(in Polish) Genetics WMCM-NU-GE-CW-1-2
Lecture:
1. Genetics as a science, the most important discoveries / DNA structure, genes, genetic code, gene expression: transcription in Procaryota, transcription in Eucaryot
2. Ribonucleic acid: transfer (tRNA), ribosomal (rRNA), informative (mRNA); splicing, alternative splicing, RNA editing. Epigenetic regulation of gene expression.
3. Translation [translation in Procaryota, translation in Eucaryot, stages: initiation, elongation, termination, post-translational modifications] / DNA replication [replication in Procaryota, replication in Eucaryot]
4. Mutations: gene level mutations, chromosomal mutations
5. Diseases caused by gene mutations, diseases caused by chromosomal mutations
7. Mutagens and DNA repair
8. Eukaryotic viruses [viral genomes, structure of viruses, replication strategies, DNA viruses, RNA viruses, retroviruses]
9. Basics of Mendelian genetics [basic assumptions, one-character crosses, heterozygous recognition, multiple alleles]
10. Mendelian genetics, part II [two-character crosses, epistasis, Mendel's laws, interpretation of results]; T. Morgan's chromosomal theory of heredity
11. Sex determination in Eukaryotes / sex-linked inheritance
12. Types of inheritance in Eukaryotes: autosomal dominant, autosomal recessive, mitochondrial, multifactorial
13. Methods of genome research [genetic maps, physical maps, sequential analysis, gene location; analysis of selected markers - candidates, analysis of markers covering the entire genome, so-called GWAS (Genome – WideAssociationStudy); HapMap project]
14. Genetic and environmental factors important in shaping the phenotype of the disease
Practical exercises
Genetic crosses: autosomal dominant inheritance, autosomal recessive inheritance, sex-linked recessive inheritance, sex-related dominant inheritance, epigenetic inheritance, mitochondrial inheritance;
Rules for the description of gene mutations
Principles of karyotype description
Inheritance of human blood groups (ABO system, Lewis system, Kell system, Rh)
Fundamentals of diagnostics of gene and chromosomal mutations, responsible for hereditary and acquired diseases, including cancer
Types of biological materials used in genetic diagnostics; rules for collecting, collecting and transporting material for testing
(in Polish) E-Learning
(in Polish) Grupa przedmiotów ogólnouczenianych
Subject level
Learning outcome code/codes
Type of subject
Course coordinators
Learning outcomes
Knowledge
A.W10. discusses the functions of the genome, transcriptome and human proteome, and basic concepts of regulating gene expression, including epigenetic regulation;
A.W11. describes the structure of chromosomes and the molecular basis of mutagenesis; knows the metabolic profiles of basic organs;
A.W12. lists the rules for inheriting different numbers of traits, inheriting quantitative traits, independent inheriting traits, and inheriting non-nuclear genetic information;
Skills
A.U6. estimates the risk of disclosure of a given disease based on the principles of inheritance and the impact of environmental factors;
A.U13. uses knowledge of genetically determined diseases in cancer prevention and prenatal diagnosis
Assessment criteria
Obtaining a positive assessment is conditioned by:
attendance at least 90% of all classes and a positive assessment of partial colloquia in a test form, carried out after each exercise, covering questions from the material of previous exercises; student receives a grade from the colloquium according to the following point thresholds:
51 - 60% - sufficient
61 - 70% - a sufficient plus
71 - 80% - good
81 - 90% - a good plus
91 - 100% - very good
The final grade is the arithmetic average of all partial grades.
Practical placement
not applicable
Additional information
Additional information (registration calendar, class conductors, localization and schedules of classes), might be available in the USOSweb system: