Population Genetics WB-BI-ANG-22cw
Biological variation, its causes and effects. Phenotypic and genotypic variation. Mechanisms of gene action, Methods of measuring variation – qualitative and quantitative characteristics of a population. Polymorphism,
Genes in populations. Hardy-Weinberg rule, concepts of Mendelian genetics – alleles and genotypes. Interactions among alleles. Heritability of phenotypic characters.
Directional forces of evolution: Mutations, neutral evolution, mutation-selection equilibrium as a result of Probeble Muation Effects. The necessity of selection. Artificial selection and vicissitudes of eugenics. Sexual selection in humans.
Natural selection, its definition. Darwinian fitness, Gradualism, punctuations. Forms of natural selection – stabilizing and directional, their examples in human populations. Measures of the opportunity for natural selection.
Genes in an isolated population. Genetic drift, inbreeding and their effects. Measuring inbreeding – kinship and inbreeding coefficients. Isonymy. Positive and negative assortative mating. The level of inbreeding in human populations.
Gene flow and its effects. Influence of neighbor contacts and mass migrations on genetic structure of populations and of the entire species. The concept of isolation by distance and genetic distances among human populations.
Interpretation of past and future human evolution in terms of population genetics.
Grupa przedmiotów ogólnouczenianych
Poziom przedmiotu
Symbol/Symbole kierunkowe efektów uczenia się
Typ przedmiotu
Koordynatorzy przedmiotu
Efekty kształcenia
Knowledge:
BI2_W01 – Student understands the complex phenomena and biological processes associated with human population genetics
BI2_W02 – Student is consistently based on empirical foundations in the interpretation of biological phenomena and processes and fully understands the importance of mathematical and statistical methods in human population genetics
BI2_W03 - Student has deep knowledge in the sciences related to human populations genetics, in particular in biochemistry
BI2_W04 – Student has an increased knowledge of the most important problems in the various departments of human population genetics and knows their connection to other natural disciplines
BI2_W06 – Student has knowledge of statistics on the level of phenomena and natural processes and has knowledge of specialized IT tools in human population genetics
Skills:
BI2_U02 – Student fluently uses human population genetic literature in Polish; He reads scientific texts in English
BI2_U04 – Student performs research tasks in human population genetics allocated by a supervisor and under his/her direction
BI2_U05 – Student uses statistical and IT techniques to describe phenomena and analyze data from human population genetics
BI2_U06 – The student collects and interprets empirical data from the human population genetics and makes appropriate conclusions based on them
BI2_U10 – Student is able to present an oral presentation on specific topics in the field of human population genetics
Social competencies:
BI1_K02 –Student is able to cooperate and work within a group, playing different roles
BI1_K07 – Student systematically updates the knowledge of human population genetics and knows its practical applications
ECTS - lectures and tutorials: 3
ECTS - lectures
ECTS [1 ECTS=30 hours]
Participation in lectures: 15 hours
Preparation for exam: 15 hours
Total: 30 hours
ECTS: 30/30=1
ECTS- tutorials
Participation in tutorials: 30 hours
Preparation for tutorials: 30 hours
Total: 60 hours
ECTS: 60/30=2
Kryteria oceniania
Knowledge (BI1_W01, 02, 03, 04, 06)
Grade 2 (fail): Student does not understand the complicated phenomena and processes in human population genetics, does not know the main problems in different disciplines of population genetics and the research methods used in it.
Grade 3 (sufficient): Student understands in a limited degree the complicated phenomena and processes in human population genetics, has limited knowledge of the most important problems of various branches of this discipline of science and methodological application in population genetics
Grade 4 (good): Student well understands the complicated phenomena and processes in human population genetics, possesses good knowledge of the most important problems of various branches of this discipline of science and methodological application in population genetics
Grade 5 (excellent): Student understands very well the complicated phenomena and processes in human population genetics, has excellent knowledge about main problems in different branches of this discipline of science and methodological applications in population genetics
Skills (BI1_U02, 04, 05, 06, 10):
Grade 2 (fail): Student does not understand population genetic literature in Polish and scientific texts in English, is not able to: prepare oral presentation, apply techniques of informatics and statistics, perform research tasks allocated by a supervisor , interpret empirical data and formulate correct conclusions
Grade 3 (sufficient): Student understands in limited degree population genetic literature in Polish and scientific texts in English, is able in limited degree to: prepare oral presentation, apply techniques of informatics and statistics, perform research tasks allocated by a supervisor , interpret empirical data and formulate correct conclusions
Grade 4 (good): Student well understands population genetic literature in Polish and scientific texts in English, is able to: prepare oral presentation, apply techniques of informatics and statistics, perform research tasks allocated by a supervisor, interpret empirical data and formulate correct conclusions
Grade 5 (excellent): Student very well understands population genetic literature in Polish and scientific texts in English, very well is able to: prepare oral presentation, apply techniques of informatics and statistics, perform research tasks allocated by a supervisor, interpret empirical data and formulate correct conclusions
Social competencies (BI1_K02, 07):
Grade 2 (fail): Student is not able to cooperate and work within a group, does not show a necessity of permanent actualization of his/her specific knowledge on human population genetics and does not know its practical applications
Grade 3 (sufficient): Student is partly able to cooperate and work within a group, marginally shows a necessity of permanent actualization of his/her specific knowledge on human population genetics and he/she poorly understands its practical applications
Grade 4 (good): Student is well able to cooperate and work within a group, shows a necessity of permanent actualization of his/her specific knowledge on human population genetics and he/she well understands its practical applications
Grade 5 (excellent): Student is excellent in cooperation and in his/her work within a group, always shows a necessity of permanent actualization of his/her specific knowledge on human population genetics and he/she very well understands its practical applications
Lectures:
Teaching methods: Lectures with PowerPoint presentations, problem lecture, sometimes conversational lecture
Method of assessment: test exam based on lectures
Tutorials:
Teaching methods:
Problem based practical tasks and group discussions. Students are given sheets specifying problems that they must solve selecting appropriate methods and carrying out calculations. Their results are interpreted and discussed with other students
Assessment methods:
- formative: attendance and activity during practical classes, solutions of practical problems and presentation of written reports of practical activities.
- summative: final colloquium
Literatura
Basic literature:
1. Cavalli-Sforza L.L., Bodmer W.F., 1971. The Genetics of Human Populations. W. H. Freeman and Company, San Francisco;
2. Falconer D.S., 1974. Dziedziczenie cech ilościowych, PWN, Warszawa;
3. Malinowski A., Strzałko J. (red.), 1985. Antropologia, PWN, Warszawa - Poznań
Supplementary reading:
1. Bielicki T., Welon Z., 1962. Działanie doboru naturalnego na kształt głowy, Materiały i Prace Antropologiczne 59, 39-45;
2. Budnik A., 1991. Odziedziczalność cech dermatoglificznych człowieka – próba nowego podejścia metodycznego, Wydawnictwo Naukowe UAM, Poznań;
3. Budnik A., 2005. Uwarunkowania stanu i dynamiki biologicznej populacji kaszubskich w Polsce. Studium antropologiczne, Wydawnictwo Naukowe UAM, Poznań;
4. Budnik A., 2000. Genetic structure of historical and contemporary Kashubian populations In Poland. [In:] Human Population Genetics In Europe, (eds.) Susanne Ch., Bodzsár É. B., Eötvös University Press, Budapest, 39-58;
5. Cavalli-Sforza L.L., Menozzi P., Piazza A., 1994. The History and Geography of Human Genes. Princeton University Press, Princeton, New Jersey;
6. Crawford M., 2007. Anthropological Genetics. Cambridge University Press, Cambridge;
7. Crow J. F., 1958. Some Possibilities for Measuring Selection Intensities in Man, Human Biology, 30, 763-775;
8. Crow J. F., Mange A. P., 1965. Measurement of inbreeding from the frequency of marriages between persons of the same surname, Eugenics Quartely, 12, 199-203;
9. Hartl D. L., Clark A. G., 2009. Podstawy genetyki populacyjnej. Wydawnictwo Uniwersytetu Warszawskiego, Warszawa;
10. Henneberg M. ,1975. Notes on the reproduction possibilities of human prehistorical populations, Przegląd Antropologiczny, 41, 75-89;
11. Henneberg M., 1876. The influence of natural selection on brachycephalization in Poland, Studies in Physical Anthropology, 3, 3-19;
12. Henneberg M., 1983. Redukcje strukturalne w mikroewolucji H.sapiens, Przegląd Antropologiczny, 49, 57-76;
13. Henneberg M., 1978, Ocena dynamiki biologicznej wielkopolskiej dziewiętnastowiecznej populacji wiejskiej. III. Opis stanu puli genów na podstawie danych demograficznych, Przegląd Antropologiczny 44, 33-52
14. Henneberg M. ,1979. Breeding isolation between populations; theoretical model of mating distances distribution, Studies in Physical Anthropology, 5, 81-94;
15. Henneberg M., Henneberg R., 1980. Ocena wpływu różnych źródeł na zmienność fenotypową człowieka, Przegląd Antropologiczny, 46, 297-307;
16. Henneberg M., Budnik A., Pezacka M., Puch A. E., 1984. Mechanizm procesu brachycefalizacji: różnicowa wrażliwość na choroby inwazyjne wieku dziecięcego. Doniesienie wstępne, Przegląd Antropologiczny 50, 325-333;
17. Henneberg M., Lewicki P.,1978. Ekosensytywność cech metrycznych - próba innego ujęcia metodycznego, Przegląd Antropologiczny, 44, 87-102;
18. Henneberg M., Piontek J., 1975, Biological State Index of Human Groups, Przegląd Antropologiczny 41, 191-200;
19. Krzanowska H., Łomnicki A., Rafiński J., 1982. Wprowadzenie do genetyki populacji. PWN, Warszawa;
20. Krzanowska H., Łomnicki A., Rafiński J., Szarski H., Szymura J. M., 1995. Zarys mechanizmów ewolucji. PWN, Warszawa;
21. Stone L., Lurquin P. F., 2009. Geny, kultura i ewolucja człowieka. Wydawnictwo Uniwersytetu Warszawskiego, Warszawa
22. Welon Z., 1962. Genetyczny model dziedziczenia kształtu głowy, Materiały i Prace Antropologiczne 59, 51-61
Więcej informacji
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